Revisiting standardized skin surface biopsy to demonstrate Demodex mite

Demodex folliculorum in rosacea based on a modified standardized skin surface biopsy

Introduction. Rosacea is a chronic disease characterized by (depending on the subtype) facial prolonged erythema, sometimes pustules or nodules. Rosacea affects all ages and sex with four subtypes. Pathophysiology aims to many different trigger factors like sun exposure, emotional stress or changed intestinal flora. Studies about Demodex mites according to different authors revealed that they m...

Demodex Mite Density Determinations by Standardized Skin Surface Biopsy and Direct Microscopic Examination and Their Relations with Clinical Types and Distribution Patterns

BACKGROUND Demodicosis is a parasitic skin disease caused by Demodex mites, and the determination of mite density per square centimeter is important to diagnose demodicosis. Standardized skin surface biopsy (SSSB) and direct microscopic examination (DME) are commonly used to determine Demodex mites density (Dd). However, no study has previously compared these two methods with respect to clinica...

non-invasive skin surface biopsy: an easy technique to detect demodex folliculorum

Demodex Mite, Rosacea and Skin Melanoma; Coincidence or Association?

OBJECTIVE To examine the possible associations between Demodex folliculorum and a number of skin diseases. METHODS Standardized skin surface biopsy samples were obtained from the cheeks of 144 patients with histopathologically proven basal cell carcinoma (BCC, n = 27), squamous cell carcinoma (SCC, n = 28), melanoma (n = 23), discoid lupus erythematosus (DLE, n = 32), and rosacea (n = 34). Th...

Human Demodex Mite: The Versatile Mite of Dermatological Importance

Demodex mite is an obligate human ecto-parasite found in or near the pilo-sebaceous units. Demodex folliculorum and Demodex brevis are two species typically found on humans. Demodex infestation usually remains asymptomatic and may have a pathogenic role only when present in high densities and also because of immune imbalance. All cutaneous diseases caused by Demodex mites are clubbed under the ...